我要來打E2了

monkeyb307

原帖由 屏東阿鴻 於 2011-8-4 22:22 發表
問個問題:
       如果母豬打E2    出生的小豬在第9週補一針淡水豬瘟

請教一下下各位的看法??

依照抗體力價可持續10-14周
9周打活毒是白打會被移行抗體干擾

gordonx

台灣地處亞熱帶，豬場飼養密度極高，豬場管理人員自我意識也極高...
為什麼這麼多屬於台灣人(大陸也是這樣)的特質卻硬是要把歐美的東西強套在這個不一樣的人與豬上。
疫苗打這麼多真的是好嗎?
大三時病毒學老師賴秀穗教授說HC是中國人很大的驕傲也很有效...當時候不太了解...不過養過3000頭以上母豬後我完全確認這一點...淡水豬瘟疫苗真是便宜又有效...有這麼好的東西，廠商硬是要從國外引進個貴超過10倍的疫苗，並且聲稱超有效?  試問各位養豬戶，你們的錢這麼好賺嗎? 怎麼一說到疫苗花錢就這麼大方，殊不知疫苗在養豬哲學裡不過只有10%的重要(不過重要的如果不打那麼就一定0分)，有一定這樣瘋狂亂打疫苗嗎?
壓低成本，提高育成率，提高售價，只要能做到以上三者相信養豬事業在台灣是大有可為的，進可攻(大陸)退可守(美加豬肉進不來)，何樂而不為呢?

Babyface

廠商硬是要從國外引進個貴超過10倍的疫苗，並且聲稱超有效?

這個疫苗是國內中興大學教授們的傑作
拜耳好像買了專利

貴哥

豬瘟會很難搞嗎????打了幾十年全世界最好的豬瘟疫苗以後,大家場裡還有典型豬瘟嗎?
明明是呼吸道的問題
牽拖PCV2
現在有了PCV2的疫苗.....還是不行
換牽拖HC
現在也有了E2
如果再不行........下次還要牽拖什麼呢?
越是牽拖,越是商機無限:026

AbiM

原帖由 Babyface 於 2011-8-3 21:11 發表
照理講.
母豬最好不要打活毒.(反應很大.怕發生事故)
但.通常pr的死毒.都不便宜.

因此大家就懶得採購兩種疫苗.而將活毒也用在母豬上.
(沒發生問題.就沒問題.)

除了.不要同時注射兩種活毒的限制外.
好像沒有 ...

你是指當天施打兩種疫苗
只要非活毒   打在同一邊
是沒關係的嗎???

還是說只要非活毒    非當天打    也可以打同一邊???

蘇少儀

Live attenuated vaccines were demonstrated to be very efficient at preventing disease. The first immunisation experiments with live attenuated lapinised strains (attenuated after serial passages in rabbits) were performed over 60 years ago (Koprowski et al., 1946). Since then, little progress has been made in this field. CSFV attenuated vaccines are safe, induce high levels of neutralising antibodies and are capable of protecting against highly virulent strains of CSFV, even in pregnant sows as early as 5 days after vaccination. Attenuated CSFV vaccines remain the method of choice to control the disease, especially in areas in which CSF remains enzootic.
The mechanisms mediating the protection conferred by attenuated strains of CSFV are not fully understood. Vaccinated animals are protected against disease before neutralizing antibodies are detected (Suradhat et al., 2001). After vaccination with the C strain, antibodies are detectable as early as 12 days post-immunisation, reaching a peak at 4–12 weeks (Precausta et al., 1983; Terpstra et al., 1990). Antibodies can persist for life in animals that have received a single dose of vaccine (Terpstra and Tielen, 1976).
Two vaccines licensed by the European Agency for the Evaluation of Medicinal Products (EMEA) are commercially available (Bayovac CSF, Bayer; Porcilis Pestis, Intervet). Vaccinated animals develop specific antibodies that exclusively recognize the E2 glycoprotein, whereas pigs infected with field strains of CSFV also develop antibodies against the Erns protein, which can be distinguished with a specific enzyme-linked immunosorbent assay (ELISA) (de Smit et al., 2001). Despite the advantages of using subunit vaccines, their protective efficacy is still under evaluation (Paton and Greiser-Wilke, 2003; Greiser-Wilke and Moennig, 2004).
Compared with classical attenuated vaccines, the protection conferred with subunit vaccines is much more limited, especially among pregnant sows, and there is a higher risk of establishment of persistently infected individuals (Ahrens et al., 2000; Depner et al., 2001; de Smit et al., 2001; Paton and Greiser-Wilke, 2003; van Oirschot, 2003b; Greiser-Wilke and Moennig, 2004; Vannier, 2004).
Two final reasons, both related to the lack of efficient differential diagnostic methods, have contributed to the non-implementation of these vaccine strategies as an emergency measure in the field (Vannier, 2004). Firstly, specific antibodies against Erns are not developed until 3–6 weeks after natural infection with field strains of CSFV (depending on the virulence of the CSFV strain), which makes the differential diagnosis at early stages of infection difficult (de Smit et al., 2000). Secondly, the available Erns based ELISAs are still far from being as sensitive and specific as the E2 based ELISAs (Greiser-Wilke and Moennig, 2004).


摘錄國際知名專家對於豬瘟活毒疫苗及次單位疫苗的看法供大家參考
這些專家只是重述疾病，免疫及疫苗的一些基本常識．而且專家都做了也研讀過相關文獻
臺灣的獸醫師很久沒機會看到豬瘟這個病了，再亂下去，現場見習的機會可能會大增

偉大的發明或發展是能夠解決產業的問題
而不是製造更大的問題

[ 本帖最後由 蘇少儀 於 2011-8-7 09:42 編輯 ]

ppplllkkk

請問一下~你們標示分娩前打~五~三週~為什麼生後的小豬是要打~四~八週<如果我沒記錯的話~~

疑行抗體是到10~14週~這樣的說法是不是有點矛盾~!!??

如果是求平均12週的小豬已經很大了~~在那時不管是打~e2或lpc這樣對小豬的緊迫會是如何!!

就你們的報告說名~有打e2跟lpc在攻毒或在排毒上裡面因應沒什麼差別吧!!<田間試驗是這樣~你們也不可能全部都在田間攻毒吧!!?

AbiM

我不打E2了
太麻煩了
而且　有人可以只打兔化
就有九成育成率
所以  我不打了

蘇少儀

Live attenuated vaccines were demonstrated to be very efficient at preventing disease.
The first immunisation experiments with live attenuated lapinised strains (attenuated after serial passages in rabbits) were performed over 60 years ago (Koprowski et al., 1946). Since then, little progress has been made in this field. CSFV attenuated vaccines are safe, induce high levels of neutralising antibodies and are capable of protecting against highly virulent strains of CSFV, even in pregnant sows as early as 5 days after vaccination.
雖然，各個兔化豬瘟減毒疫苗株（經由兔子連續繼代進行減毒）首度進行免疫試驗距今已60多年了，但是，豬瘟減毒疫苗經驗證對疾病預防上具有非常好的效果，而且即便田間使用兔化豬瘟疫苗，從那個年代起迄今其間的進展有限，然而豬瘟減毒疫毒仍是安全，誘發高度中和抗體而且能夠保護疫苗接種豬隻；即便是懷孕母豬在接種疫苗後的五天後即能夠產生對抗各個高毒力豬瘟病毒株的保護效果．
Attenuated CSFV vaccines remain the method of choice to control the disease, especially in areas in which CSF remains enzootic.
The mechanisms mediating the protection conferred by attenuated strains of CSFV are not fully understood. Vaccinated animals are protected against disease before neutralizing antibodies are detected (Suradhat et al., 2001).
After vaccination with the C strain, antibodies are detectable as early as 12 days post-immunisation, reaching a peak at 4–12 weeks (Precausta et al., 1983; Terpstra et al., 1990). Antibodies can persist for life in animals that have received a single dose of vaccine (Terpstra and Tielen, 1976).
接種減毒豬瘟疫苗仍為控制豬瘟的方法之一，尤其是仍然發生豬瘟病例的區域．接種減毒豬瘟疫苗後，豬隻在中和抗體被檢出之前即具有保護效果，雖然此一保護效果的機制仍待釐清．接種豬瘟C株疫苗（註：類似臺灣使用的LPC株）後，最早可在接種後12天測得抗體，抗體力價在第4至12週時達到高峰．曾有文獻指出，豬隻在免疫適期接種一劑兔化豬瘟減毒疫苗，抗體可持續終身．
Two vaccines licensed by the European Agency for the Evaluation of Medicinal Products (EMEA) are commercially available (Bayovac CSF, Bayer; Porcilis Pestis, Intervet).  Vaccinated animals develop specific antibodies that exclusively recognize the E2 glycoprotein, whereas pigs infected with field strains of CSFV also develop antibodies against the Erns protein, which can be distinguished with a specific enzyme-linked immunosorbent assay (ELISA) (de Smit et al., 2001). Despite the advantages of using subunit vaccines, their protective efficacy is still under evaluation (Paton and Greiser-Wilke, 2003; Greiser-Wilke and Moennig, 2004).
Bayovac CSF, Bayer及Porcilis Pestis, Intervet等二種經歐盟醫療產品評估機構（EMEA）核准上市的疫苗，使用此二種疫苗接種豬隻後產生的抗體只與豬瘟病毒結構上特定的E2醣蛋白（E2 glycoprotein）結合，而豬隻感染野外病毒株後，除對E2醣蛋白產生抗體外，亦對Erns蛋白質產生抗體，因此可應用此一差異，使用檢測Erns蛋白質的酵素連結免疫吸附法（ELISA）作為區別疫苗接種或野外病毒感染之用．估不論次單位疫苗的優點，其保護效力仍在評估之中．
Compared with classical attenuated vaccines, the protection conferred with subunit vaccines is much more limited, especially among pregnant sows, and there is a higher risk of establishment of persistently infected individuals (Ahrens et al., 2000; Depner et al., 2001; de Smit et al., 2001; Paton and Greiser-Wilke, 2003; van Oirschot, 2003b; Greiser-Wilke and Moennig, 2004; Vannier, 2004).
相較於傳統的減毒疫苗，接種次單位疫苗所產生的保護效果相當有限；尤其是懷孕母豬，而且發生豬隻持續性感染方面具有非常高的風險．
Two final reasons, both related to the lack of efficient differential diagnostic methods, have contributed to the non-implementation of these vaccine strategies as an emergency measure in the field (Vannier, 2004). Firstly, specific antibodies against Erns are not developed until 3–6 weeks after natural infection with field strains of CSFV (depending on the virulence of the CSFV strain), which makes the differential diagnosis at early stages of infection difficult (de Smit et al., 2000). Secondly, the available Erns based ELISAs are still far from being as sensitive and specific as the E2 based ELISAs (Greiser-Wilke and Moennig, 2004).
最後二個與現今仍缺乏有效區別診斷方法有關，而無法使用次單位疫苗作為田間緊急接種的疫苗接種策略的理由．其一是豬隻自然感染野外豬瘟病毒株時，需要3到6週（依豬瘟病毒的毒力而定）才可測得抗Erns蛋白的抗體，這造成感染早期階段，區別診斷上的困難．其次為現有檢測Erns抗體的酵素連結免疫吸附法（ELISA）試劑的敏感性及特異性距離實用階段仍有很大的改良空間．

[ 本帖最後由 蘇少儀 於 2011-8-9 09:48 編輯 ]

219dyd

要注意產前是否可以打