The FEEDAP Panel was further of the opinion, that the uncertainties concerning the figure of a NOEL should not be balanced by a (higher) safety factor. All the uncertainties together would reach a dimension in which more or less arbitrary estimations prevail.
The FEEDAP Panel finally concluded that the human study can not be taken as a basis to derive an ADI, as proposed by JECFA, and consequently no proposal for MRLs could be made.
The FEEDAP Panel concluded that all treatment-related effects observed in the long-term studies in mice and rats were attributable to the β-adrenergic activity of ractopamine. It shares the JECFA and FDA opinion, considering that the induction of leiomyomas is a non-genotoxic event with a threshold and ractopamine is not a direct carcinogen. Considering all studies, the FEEDAP Panel concluded that ractopamine is not mutagenic and is not likely to present a carcinogenic risk to consumers.
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The CVMP fully supported the conclusions of the FEEDAP Panel with regard to the safety evaluation of ractopamine.
The FEEDAP Panel proposed to use the sum of free ractopamine and ractopamine glucuronoconjugates (sensitive analytical methods available, NRCP of the EU) instead of free ractopamine as marker substance, a view supported by CVMP.
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下面這句話是個人意見;
萊特多巴胺對消費者沒有致突變及不像是有致癌風險(其他類似物,報告中未論及,所以不在此範圍)
但就the β-adrenergic activity的風險而言,其實可以用類似香菸盒上的警語在肉品上標示高風險族群