CHAPTER I--FOOD AND DRUG ADMINISTRATION
DEPARTMENT OF HEALTH AND HUMAN SERVICES
SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS
PART 556 -- TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD
Subpart B--Specific Tolerances for Residues of New Animal Drugs
Sec. 556.570 Ractopamine.
(a)Acceptable Daily Intake (ADI) . The ADI for total residues of ractopamine hydrochloride is 1.25 micrograms per kilogram of body weight per day.
(b)Tolerances --(1)Cattle --(i)Liver (the target tissue). The tolerance for ractopamine hydrochloride (the marker residue) is 0.09 parts per million (ppm).
(ii)Muscle. The tolerance for ractopamine hydrochloride (the marker residue) is 0.03 ppm.
(2)Swine --(i)Liver (the target tissue). The tolerance for ractopamine hydrochloride (the marker residue) is 0.15 ppm.
(ii)Muscle. The tolerance for ractopamine hydrochloride (the marker residue) is 0.05 ppm.
(3)Turkeys --(i)Liver (the target tissue) . The tolerance for ractopamine (the marker residue) is 0.45 ppm.
(ii)Muscle . The tolerance for ractopamine (the marker residue) is 0.1 ppm.
[68 FR 54659, Sept. 18, 2003, as amended at 73 FR 72715, Dec. 1, 2008]
The FSIS CLG Method, Screening and Confirmation of Beta-Agonists by HPLC-MS-MS (High Performance Liquid Chromatography – Mass Spectrometry), has been updated with technical improvements and fitted with text to align it with ISO 17025 standards.
These technical improvements include lowering the level of applicability for one analyte (ractopamine, a beta-agonist used to promote growth in production animals) from 21 ppb to 3 ppb as well as streamlining the extraction of samples.
The method will be posted to the FSIS Chemistry Laboratory Guidebook once finalized, with an effective date no earlier than January 17, 2012.
CHAPTER I--FOOD AND DRUG ADMINISTRATION
DEPARTMENT OF HEALTH AND HUMAN SERVICES
SUBCHAPTER E--ANIMAL DRUGS, FEEDS, AND RELATED PRODUCTS
PART 556 -- TOLERANCES FOR RESIDUES OF NEW ANIMAL DRUGS IN FOOD
Subpart B--Specific Tolerances for Residues of New Animal Drugs
Sec. 556.570 Ractopamine.
(a)Acceptable Daily Intake (ADI) . The ADI for total residues of ractopamine hydrochloride is 1.25 micrograms per kilogram of body weight per day.
(b)Tolerances --(1)Cattle --(i)Liver (the target tissue). The tolerance for ractopamine hydrochloride (the marker residue) is 0.09 parts per million (ppm).
(ii)Muscle. The tolerance for ractopamine hydrochloride (the marker residue) is 0.03 ppm.
(2)Swine --(i)Liver (the target tissue). The tolerance for ractopamine hydrochloride (the marker residue) is 0.15 ppm.
(ii)Muscle. The tolerance for ractopamine hydrochloride (the marker residue) is 0.05 ppm.
(3)Turkeys --(i)Liver (the target tissue) . The tolerance for ractopamine (the marker residue) is 0.45 ppm.
(ii)Muscle . The tolerance for ractopamine (the marker residue) is 0.1 ppm.
[68 FR 54659, Sept. 18, 2003, as amended at 73 FR 72715, Dec. 1, 2008]