[轉貼]丁酸鈉在仔豬飼料減少腹瀉

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一種添加丁酸鈉豬仔的飼料中的好處是斷奶後腹瀉，這是最常見的解釋為發病率和死亡率在這個年齡段觀察到的減少。

在最近的一篇文章（J.阿尼姆。科學，2012），馬等。試圖了解其中機制丁酸鈉能降低腹瀉的發生率。在體外實驗中，培養的細胞被劃傷誘導的傷口，然後分別用丁酸鈉處理。該出版物表明，添加丁酸鈉加速傷口癒合的過程，確認丁酸對腸粘膜的保護作用。時相比，對照組中，作者觀察到腸黏膜緊密連接蛋白的mRNA的表達occludin和小帶occluden蛋白-1增加。此外，在丁酸鹽處理的細胞，超氧化物歧化酶，穀胱甘肽過氧化物酶，2的電平主要的抗氧化酶，以及穀胱甘肽，非酶促抗氧化劑成分之一，較對照組顯著更高。還有，丙二醛，自由基介導的脂質過氧化損傷的標記物，是存在於在用丁酸鈉處理的細胞中水平較低。這些結果證實了以前的研究表明的在腸中丁酸鈉的好處之一是維持腸屏障的功能。連同Peng等人的報告中。（2009），本研究還表明，添加丁酸鈉在飼料大概可以維持腸道緊密連接，這是必不可少的保持腸道完整性方面發揮重要作用。

原文：

Sodium butyrate in piglet feed reduces diarrhoea

One of the benefits of adding sodium butyrate in the feed of piglets is the reduction of post weaning diarrhoea, which is one of the most frequent explanations for the morbidity and mortality observed at this age.

In a recent paper (J. Anim. Sci. 2012), Ma et al. tried to understand by which mechanism sodium butyrate can decrease the incidence of diarrhoea. In an in-vitro experiment, cultured cells were scratched to induce wound, then were treated with sodium butyrate. The publication shows that addition of sodium butyrate accelerated the process of wound healing, confirming a protecting effect of butyrate on the intestinal mucosa. When compared to a control group, the authors observed that mRNA expression of the intestinal mucosal tight junction proteins occludin and zonula occluden protein-1 was increased.

Besides, in the butyrate-treated cells, the levels of superoxide dismutase and glutathione peroxidase, two of the main antioxidant enzymes, as well as glutathione, one of the nonenzymatic antioxidant components, were significantly higher than in the control group.  Also, malondialdehyde, a marker of free radical mediated lipid peroxidation injury, was present at lower levels in the cells treated with sodium butyrate. These results confirm previous research suggesting that one of the benefits of sodium butyrate in the intestine is to maintain the function of the intestinal barrier.

Together with the report of Peng et al. (2009), this study also indicates that adding sodium butyrate in feed can probably play an important role in maintaining the intestinal tight junctions, which are essential to preserve the gut integrity.

Source: Norel

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